Gene information
Official symbol CST3
Official full name cystatin C
Gene type protein-coding gene
Chromosome20p11.21
Gene familyCystatins, type 2
Resources
Entrez Gene 1471
HGNC HGNC:2475
Ensembl ENSG00000101439
Vega OTTHUMG00000032080
UCSC uc002wtm.5
GO terms: 31 records
GO Description Category LogP Number of genes Detail
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004869 cysteine-type endopeptidase inhibitor activity GO Molecular Functions -4.04506120 6 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010712 regulation of collagen metabolic process GO Biological Processes -14.4967625 19 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0034104 negative regulation of tissue remodeling GO Biological Processes -6.91942497 9 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0097435 supramolecular fiber organization GO Biological Processes -6.48496756 24 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:1903018 regulation of glycoprotein metabolic process GO Biological Processes -5.51204462 13 More
GO:1903053 regulation of extracellular matrix organization GO Biological Processes -8.17680088 15 More
GO:1904724 tertiary granule lumen GO Cellular Components -12.6232675 13 More
GO:1904813 ficolin-1-rich granule lumen GO Cellular Components -6.12299383 11 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
digoxin NCI 17698593 view
ribavirin NCI 18637076 view
Related studies: 23 records
Molecular factor Omics type Application Objective MI type Reference
cystatin-C proteomics poor predictor congestive heart failure[prognosis (bad)] acute ST elevation myocardial infarction Ichimoto E et al. Circ J. 2009
cystatin-C proteomics left ventricular dysfunction[prognosis (bad)] ST elevation myocardial infarction Derzhko R et al. Coron Artery Dis. 2009
cystatin-C proteomics cardiogenic shock;death[prognosis (bad)] acute ST elevation myocardial infarction Silva D et al. Am J Cardiol. 2012
cystatin-C proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Silva D et al. Am J Cardiol. 2012
cystatin-C proteomics death;recurrent myocardial infarction[prognosis (bad)] acute ST elevation myocardial infarction Silva D et al. Am J Cardiol. 2012
cystatin-C proteomics good predictor acute kidney failure[prognosis (bad)] acute myocardial infarction Fouad M et al. Arab J Nephrol Transplant. 2013
cystatin-C proteomics medium predictor death[prognosis (bad)] acute myocardial infarction Fouad M et al. Arab J Nephrol Transplant. 2013
cystatin-C proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Wei S et al. Herz. 2014
cystatin-C proteomics medium predictor cardiovascular death[prognosis (bad)] acute ST elevation myocardial infarction Akgul O et al. J Crit Care. 2013
cystatin-C proteomics medium predictor acute kidney failure[prognosis (bad)] acute ST elevation myocardial infarction Tung YC et al. PLoS One. 2015
cystatin-C proteomics medium predictor major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Abid L et al. J Saudi Heart Assoc. 2016
cystatin-C proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Alhusseiny AH et al. Cardiol Res. 2015
cystatin-C proteomics adverse events[prognosis (bad)] acute myocardial infarction von Jeinsen B et al. Int J Cardiol. 2017
cystatin-C proteomics adverse events[prognosis (bad)] ST elevation myocardial infarction Shen G et al. Am J Med Sci. 2018
cystatin-C proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Fu Z et al. Clin Interv Aging. 2018
cystatin-C proteomics death[prognosis (bad)] acute myocardial infarction Fu Z et al. Clin Interv Aging. 2018
cystatin-C proteomics death[prognosis (bad)] ST elevation myocardial infarction Chen Y et al. Clin Cardiol. 2019
cystatin-C proteomics cardiovascular death[prognosis (bad)] ST elevation myocardial infarction Chen Y et al. Clin Cardiol. 2019
cystatin-C proteomics no-reflow phenomenon[prognosis (bad)] acute anterior ST elevation myocardial infarction Cheng C et al. PLoS One. 2019
cystatin-C proteomics excellent predictor infarct-related artery patency[prognosis (good)] ST elevation myocardial infarction Doganay B et al. Acta Cardiol Sin. 2019
cystatin-C proteomics good predictor acute kidney failure[prognosis (bad)] acute myocardial infarction Pei Y et al. Cardiorenal Med. 2020
cystatin-C proteomics poor predictor adverse events[prognosis (bad)] acute myocardial infarction Fuernau G et al. Int J Cardiol. 2015
cystatin-C proteomics type 2 myocardial infarction[diagnosis] type 2 myocardial infarction Gaggin HK et al. Circulation. 2017
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